Successful aging may be defined as the separation of the natural aging process from the development of chronic diseases in later life. There is strong indication that reduction of inflammation is a hallmark of successful aging. There are suggestions from the literature that high-dose fish oil may be a useful dietary intervention in the reduction of inflammation. This review will summarize that data. The primary problem for its widespread utilization may not be the safety of high-dose fish oil, but increasing the production of finished products for a global population.