The skin is the largest organ in the human body and plays a significant role in protecting the body from external threats, containing tissues that sustain the body's homeostasis. Wound healing in the skin is a complex process involving the interaction of various cell types in the target tissue, including but not limited to cytokines and growth factors. In extreme cases, disorders of the cardiorespiratory system, such as chronic diseases, may prevent the process of wound healing entirely. Numerous studies have been conducted to discover methods to restore the ability of chronic wounds to cure themselves, but this remains one of the most significant medical problems. Exosomes derived from stem cells have been extensively proposed as a treatment for dermal wound recovery. Different types of stem cells have varying therapeutic potential. Exosomes, a component of paracrine, have the function of enhancing the effectiveness of stem cells. This article discusses the wound healing process as well as the mechanism of stem cell and adipose-derived exosome therapy on cutaneous wound healing and its clinical applications.