Good vascularity and large surface for implantation make the omentum a promising site for implant of islet transplantation alternatively to the liver. The first successes of these procedures have further increased the interest toward the omentum. In particular, the strategy suggested by the University of Miami, which includes the use of autologous plasma and thrombin, seems to result in a promotion of the revascularization process and encourages further exploration of this islet transplant site. This transplant strategy could also allow for the introduction of additional local immunoprotective agents, stimulating an even wider interest.