Immunofluorescence microscopy of human adipose-derived stromal vascular fraction (SVF), identifying cellular components (blue – DAPI), leukocytes (red – CD45) and stromal/vascular progenitor cells (green – CD34). Courtesy of Dr. Severiano Dos Anjos, Ph.D; the GID group.

CellR4, the official journal of The Cure Alliance, is a journal with a particular focus on cellular repair, replacement, regeneration, reprogramming, and differentiation.

Its scope ranges from fundamental new discoveries in basic science to translational, clinical trials and delivery of novel therapeutic options.

CellR4 aims to be also a platform for discussion of challenges and opportunities on the path to the development of new treatments, independently from the disease target.

CellR4 will also publish commentaries and opinion papers on regulatory, legal, and ethical issues, as well as publish information on global collaborative platforms and funding opportunities.

The full text of the articles can be downloaded free of charge.

 

 

Adipose-derived stromal vascular fraction (SVF) cells in the treatment of rheumatoid arthritis of the hand

CellR4 2018; 6 (3): e2533

  Topic: Regenerative Surgery     Category:

Carstens M.
Clinical Associate Professor of Plastic Surgery, Saint Louis University, St. Louis, MO, USA
michaelcarstens@mac.com Close
, Montenegro J. J.
Hospital Escuela Militar Dr. Alejandro Dávila Bolaños, Managua, Nicaragua Close
, Gomez A.
Department of Plastic Surgery, Universidad Nacional Autónoma de Nicaragua, León, Nicaragua Close
, Correa D.
Department of Orthopedics, Division of Sports Medicine, University of Miami, Miller School of Medicine, Miami, FL, USA Close

Automated isolation and expansion of human adipose tissue-derived stem cells for a seamless translation into clinical trials

CellR4 2018; 6 (2): e2519

  Topic: Stem cell     Category:

Schive S. W.
Department of Transplant Medicine, Oslo University Hospital, Oslo, Norway Close
, Fjukstad R.
Department of Transplant Medicine, Oslo University Hospital, Oslo, Norway Close
, Josefsen D.
Section for Cell Therapy, Oslo University Hospital, Oslo, Norway Close
, Katavic M.
Department of Transplant Medicine, Oslo University Hospital, Oslo, Norway Close
, Abadpour S.
Department of Transplant Medicine, Oslo University Hospital, Oslo, Norway Close
, Gullestad H. P.
Department of Surgery, Institute for Cancer Research, Oslo University Hospital, Oslo, Norway Close
, Kvalheim G.
Section for Cell Therapy, Oslo University Hospital,, Oslo, Norway Close
, Scholz H.
Department of Transplant Medicine, Oslo University Hospital, Oslo, Norway
hanne.scholz@medisin.uio.no Close
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Allogeneic umbilical cord blood mononuclear cell therapy for spinal cord injury – a retrospective cohort study

CellR4 2018; 6 (2): e2521

  Topic: Stem cell     Category:

Mehling B. M.
BHI Therapeutic Sciences, Hackensack, NJ, USA Close
, Wu D. C.
Department of Biochemistry, Wuhan University School of Basic Medical Science, Wuhan, China Close
, Quartararo L.
BHI Therapeutic Sciences, Hackensack, NJ, USA Close
, Roman S. J.
Trenton Orthopedic Group, Hamilton Township, NJ, USA Close
, Pickoff A. S.
Wright State University, Dayton, OH, USA Close
, Stolfi A.
Wright State University, Dayton, OH, USA Close
, Szelestey B.
Wright State University, Dayton, OH, USA Close
, Rutherford R.
The Ohio State University, Columbus, OH, USA Close
, Manvelyan M.
BHI Therapeutic Sciences, Hackensack, NJ, USA
mmanvelyan@bluehorizonhospital.com Close
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Can high-dose omega-3 fatty acids and high-dose vitamin D3 (cholecalciferol) prevent type 1 diabetes and sustain preservation of beta-cell function after disease onset?

CellR4 2018; 6 (1): e2493

POSEIDON study: a pilot, safety and feasibility trial of high­-dose omega­3 fatty acids and high-­dose cholecalciferol supplementation in type 1 diabetes

CellR4 2018; 6 (1): e2489

  Topic: Diabetes     Category:

Baidal D. A.
Diabetes Research Institute and Department of Pediatrics, University of Miami Miller School of Medicine, Miami, FL, USA Close
, Sanchez J.
Diabetes Research Institute and Department of Pediatrics, University of Miami Miller School of Medicine, Miami, FL, USA Close
, Alejandro R.
Diabetes Research Institute and Department of Pediatrics, University of Miami Miller School of Medicine, Miami, FL, USA Close
, Blaschke C. E.
Diabetes Research Institute and Department of Pediatrics, University of Miami Miller School of Medicine, Miami, FL, USA Close
, Hirani K.
Diabetes Research Institute and Department of Pediatrics, University of Miami Miller School of Medicine, Miami, FL, USA Close
, Matheson D. L.
Diabetes Research Institute and Department of Pediatrics, University of Miami Miller School of Medicine, Miami, FL, USA Close
, Messinger S.
Diabetes Research Institute and Department of Pediatrics, University of Miami Miller School of Medicine, Miami, FL, USA Close
, Pugliese A.
Diabetes Research Institute and Department of Pediatrics, University of Miami Miller School of Medicine, Miami, FL, USA Close
, Rafkin L. E.
Diabetes Research Institute and Department of Pediatrics, University of Miami Miller School of Medicine, Miami, FL, USA Close
, Roque L. A.
Diabetes Research Institute and Department of Pediatrics, University of Miami Miller School of Medicine, Miami, FL, USA Close
, Vera Ortiz J. M.
Diabetes Research Institute and Department of Pediatrics, University of Miami Miller School of Medicine, Miami, FL, USA Close
, Ricordi C.
Diabetes Research Institute and Department of Pediatrics, University of Miami Miller School of Medicine, Miami, FL, USA Close
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Microencapsulated umbilical cord Wharton Jelly-derived human mesenchymal stem cells for the cell therapy of type 1 diabetes mellitus (T1d): applications and limits

CellR4 2017; 5 (6): e2467

  Topic: Diabetes, Stem cell     Category:

Montanucci P.
Department of Medicine, Section of Cardiovascular, Endocrine and Metabolic Clinical Physiology, Laboratory for Endocrine Cell Transplants and Biohybrid Organs, University of Perugia, Perugia, Italy Close
, Pescara T.
Department of Medicine, Section of Cardiovascular, Endocrine and Metabolic Clinical Physiology, Laboratory for Endocrine Cell Transplants and Biohybrid Organs, University of Perugia, Perugia, Italy Close
, Basta G.
Department of Medicine, Section of Cardiovascular, Endocrine and Metabolic Clinical Physiology, Laboratory for Endocrine Cell Transplants and Biohybrid Organs, University of Perugia, Perugia, Italy Close
, Calafiore R.
Department of Medicine, Section of Cardiovascular, Endocrine and Metabolic Clinical Physiology, Laboratory for Endocrine Cell Transplants and Biohybrid Organs, University of Perugia, Perugia, Italy Close
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Cancer microarray data weighted gene co-expression network analysis identifies a gene module and hub genes shared across nine types of solid cancer

CellR4 2017; 5 (5): e2439

  Topic: Cancer     Category:

Yu J. H.
Department of Surgery, University of Toledo, College of Medicine and Life Sciences, Toledo, Ohio, USA Close
, Liu S. H.
Department of Surgery, University of Toledo, College of Medicine and Life Sciences, Toledo, Ohio, USA Close
, Hong Y. W.
Department of Surgery, University of Toledo, College of Medicine and Life Sciences, Toledo, Ohio, USA Close
, Markowiak S.
Department of Surgery, University of Toledo, College of Medicine and Life Sciences, Toledo, Ohio, USA
smarkowiak@gmail.com Close
, Sanchez R.
Department of Surgery, University of Toledo, College of Medicine and Life Sciences, Toledo, Ohio, USA Close
, Schroeder J.
Department of Surgery, University of Toledo, College of Medicine and Life Sciences, Toledo, Ohio, USA Close
, Heidt D.
Department of Surgery, University of Toledo, College of Medicine and Life Sciences, Toledo, Ohio, USA Close
, Brunicardi F. C.
Department of Surgery, University of Toledo, College of Medicine and Life Sciences, Toledo, Ohio, USA Close
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Considerations on the harvesting site and donor derivation for mesenchymal stem cells-based strategies for diabetes

CellR4 2017; 5 (5): e2435

  Topic: Diabetes, Immune Regulation, Stem cell     Category:

Zazzeroni L.
Department of Experimental, Diagnostic and Specialty Medicine (DIMES), University of Bologna, Bologna, Italy
luca.zazzeroni2@unibo.it Close
, Lanzoni G.
Diabetes Research Institute, University of Miami, Miami, FL, USA Close
, Pasquinelli G.
Department of Experimental, Diagnostic and Specialty Medicine (DIMES), University of Bologna, Bologna, Italy Close
, Ricordi C.
Diabetes Research Institute, University of Miami, Miami, FL, USA Close
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What’s hot and what’s new in beta-cell replacement therapy: highlights from the 16th Congress of IPITA

CellR4 2017; 5 (4): e2419

The greater omentum as a site for pancreatic islet transplantation

CellR4 2017; 5 (3): e2410

  Topic: Islet transplantation     Category:

Pellicciaro M.
Department of Experimental Medicine and Surgery, University of Rome Tor Vergata, Rome, Italy
marcopell62@gmail.com Close
, Vella I.
Department of Experimental Medicine and Surgery, University of Rome Tor Vergata, Rome, Italy Close
, Lanzoni G.
2Diabetes Research Institute and Cell Transplant Center, University of Miami, Miami, FL, USA Close
, Tisone G.
Department of Experimental Medicine and Surgery, University of Rome Tor Vergata, Rome, Italy Close
, Ricordi C.
2Diabetes Research Institute and Cell Transplant Center, University of Miami, Miami, FL, USA Close
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Treatment of late sequelae of burn scar fibrosis with adipose-derived stromal vascular fraction (SVF) cells

CellR4 2017; 5 (3): e2404

  Topic: Regenerative Medicine, Translational research     Category:

Carstens M. H.
Division of Plastic Surgery, Hospital Metropolitano Vivian Pellas, Managua, Nicaragua
michaelcarstens@mac.com Close
, Pérez M.
Division of Plastic Surgery, Hospital Metropolitano Vivian Pellas, Managua, Nicaragua Close
, Briceño H.
Division of Plastic Surgery, Hospital Metropolitano Vivian Pellas, Managua, Nicaragua Close
, Valladares S.
Asociación Pro Niños Quemados de Nicaragua (APROQUEN), Managua, Nicaragua Close
, Correa D.
Diabetes Research Institute & Cell Transplant Center, University of Miami, Miller School of Medicine, Miami, FL, USA Close
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