Therapy of osteoarthritis relies on non-steroid analgesics, chondroprotectives and in late stages total joint replacement is considered a standard of care. We performed a pilot study using novel stem cell therapy approach that was performed during one surgical procedure. It relies on abdominal lipoaspiration and processing of connective tissue to stromal vascular fraction (SVF) cells that typically contain relatively large amounts of mesenchymal stromal and stem cells. SVF cells are injected immediately to the target joint or to the connective tissue of the target joint. Since 2011, total of 1128 patients have been recruited and followed for up to 42 months to demonstrate the therapeutical potential of freshly isolated SVF cells. At the same time, one to four joints (knees and hips) were injected with SVF cells per patient. A total number of 1769 joints were treated. Clinical scale evaluation including pain, non-steroid analgesic usage, limping, extent of joint movement and stiffness was used as measurement of the clinical effect. All patients were diagnosed with stage II-IV osteoarthritis using clinical examination and X-ray, in some cases MRI was also performed to monitor the changes before and after stem cell therapy. After 12 months from SVF therapy, at least 50% clinical improvement was recognized in 81%, and at least 75% clinical improvement in 47% of patients, respectively. Within 1-2 weeks from SVF therapy 72% of patients were off the non-steroid analgesics and most of them remain such for at least 12 months. No serious side effects, infection or cancer was associated with SVF cell therapy. In conclusion, here we report a novel and promising therapeutical approach that is safe, cost effective, and relying only on autologous cells.
This work was supported in part by the International Consortium for Cell Therapy and Immunotherapy (www.iccti.eu) and Czech Ministry of Education Grant No. CZ.1.07/2.3.00/20.0012.
To cite this article
Stem Cell Therapy of Osteoarthritis Using Stromal Vascular Fraction Cells – Proceeding of the STEMSO Conference
CellR4 2014; 2 (1): e778
Published online: 05 Feb 2014