Targeting Toll-Like Receptor 4: a promising strategy to prevent type 1 diabetes occurrence or recurrence

CellR4 2020; 8: e2850
DOI: 10.32113/cellr4_20205_2850

  Topic: Diabetes, Immune Regulation, Islet transplantation     Category:

Abstract

TLR4 is a transmembrane receptor of the innate immune system that recognize LPS of gram-negative bacteria. Its stimulation induces pro-inflammatory responses and also modulates adaptive immunity. In this article, we discuss the role of TLR4 in the activation and proliferation of T cells at the onset of autoimmune diabetes. We review the pathways involved in these observations. Finally, we show how targeting TLR4, by a variety of strategies, can prevent the occurrence of the disease but also its recurrence after allogeneic islet of Langerhans transplantation.

To cite this article

Targeting Toll-Like Receptor 4: a promising strategy to prevent type 1 diabetes occurrence or recurrence

CellR4 2020; 8: e2850
DOI: 10.32113/cellr4_20205_2850

Publication History

Submission date: 14 Apr 2020

Revised on: 20 Apr 2020

Accepted on: 28 Apr 2020

Published online: 27 May 2020