TLR4 is a transmembrane receptor of the innate immune system that recognize LPS of gram-negative bacteria. Its stimulation induces pro-inflammatory responses and also modulates adaptive immunity. In this article, we discuss the role of TLR4 in the activation and proliferation of T cells at the onset of autoimmune diabetes. We review the pathways involved in these observations. Finally, we show how targeting TLR4, by a variety of strategies, can prevent the occurrence of the disease but also its recurrence after allogeneic islet of Langerhans transplantation.
To cite this article
Targeting Toll-Like Receptor 4: a promising strategy to prevent type 1 diabetes occurrence or recurrence
Submission date: 14 Apr 2020
Revised on: 20 Apr 2020
Accepted on: 28 Apr 2020
Published online: 27 May 2020
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