Original Articles

CellR4 2015; 3 (1): e1397

A novel efficient method to isolate human adipose-derived stromal cells from periumbilical biopsies without enzymatic digestion

Canazza A.
Cellular Neurobiology Laboratory, Department of Cerebrovascular Disease, Fondazione I.R.C.C.S. Istituto Neurologico “Carlo Besta”, Milan, Italy
, Bedini G.
Cellular Neurobiology Laboratory, Department of Cerebrovascular Disease, Fondazione I.R.C.C.S. Istituto Neurologico “Carlo Besta”, Milan, Italy
gloria.bedini@istituto-besta.it
, Caremoli F.
Laboratory of Pharmacology, Department of Health Sciences, University of Milan, Milan, It
, Nava S.
UPTC, Cell Therapy Production Unit, Fondazione I.R.C.C.S. Istituto Neurologico “Carlo Besta”, Milan, Italy
, Latorre E.
Laboratory of Pharmacology, Department of Health Sciences, University of Milan, Milan, Italy
, Tosetti V.
Cellular Neurobiology Laboratory, Department of Cerebrovascular Disease, Fondazione I.R.C.C.S. Istituto Neurologico “Carlo Besta”, Milan, Italy
, Taiana M.
Neuroalgology and Headache Unit, Fondazione I.R.C.C.S. Istituto Neurologico “Carlo Besta”, Milan, Italy
, Dossena M.
Cellular Neurobiology Laboratory, Department of Cerebrovascular Disease, Fondazione I.R.C.C.S. Istituto Neurologico “Carlo Besta”, Milan, Italy
, Bersano A.
Cellular Neurobiology Laboratory, Department of Cerebrovascular Disease, Fondazione I.R.C.C.S. Istituto Neurologico “Carlo Besta”, Milan, Italy
, Pareyson D.
Clinic of Central and Peripheral Degenerative Neuropathies Unit, Department of Clinical Neurosciences, Fondazione I.R.C.C.S. Istituto Neurologico “Carlo Besta”, Milan, Italy
, Grimoldi M. G.
Pathology Unit, Department of Health Sciences, University of Milan, Milan, Italy
, Corsi F.
Surgery Division, Department of Biomedical and Clinical Sciences, “L. Sacco” University of Milan, Milan, Italy
, Di Giulio A. M.
Laboratory of Pharmacology, Department of Health Sciences, University of Milan, Milan, Italy
, Parati E. A.
Cellular Neurobiology Laboratory, Department of Cerebrovascular Disease, Fondazione I.R.C.C.S. Istituto Neurologico “Carlo Besta”, Milan, Italy
, Carelli S.
Laboratory of Pharmacology, Department of Health Sciences, University of Milan, Milan, Italy
, Gorio A.
Laboratory of Pharmacology, Department of Health Sciences, University of Milan, Milan, Italy
alfredo.gorio@unimi.it

CellR4 2015; 3 (1): e1394

TGF-β3-releasing pharmacologically active microcarriers combined with human cartilage microparticles drive MIAMI cells toward a hyaline cartilage phenotype

Delcroix G. J.-R.
Department of Orthopaedics, University of Miami Miller School of Medicine, Miami, FL, USA
Gdelcroix@med.miami.edu
, D’Ippolito G.
Department of Orthopaedics, University of Miami Miller School of Medicine, Miami, FL, USA
, Reiner T.
GRECC & Research Service, Bruce W. Carter Veterans Affairs Medical Center, Miami, FL, USA
, Malinin T.
Department of Orthopaedics, University of Miami Miller School of Medicine, Miami, FL, USA
, Temple H. T.
Department of Orthopaedics, University of Miami Miller School of Medicine, Miami, FL, USA
, Montero-Menei C. N.
Inserm U1066, MINT, Angers, France
, Schiller P. C.
Department of Orthopaedics, University of Miami Miller School of Medicine, Miami, FL, USA
P.Schiller@miami.edu

CellR4 2014; 2 (6): e1289

Lipogems, a New Modality of Fat Tissue Handling to Enhance Tissue Repair in Chronic Hind Limb Ischemia

Bianchi F.
Stem Wave Institute for Tissue Healing (SWITH), Gruppo Villa Maria (GVM) Care & Research – Ettore Sansavini Health Science Foundation, Lugo (Ravenna), Italy
, Olivi E.
Stem Wave Institute for Tissue Healing (SWITH), Gruppo Villa Maria (GVM) Care & Research – Ettore Sansavini Health Science Foundation, Lugo (Ravenna), Italy
, Baldassarre M.
Department of Medical and Surgical Sciences, University of Bologna, Bologna, Italy
, Giannone F. A.
Department of Medical and Surgical Sciences, University of Bologna, Bologna, Italy
, Laggetta M.
Department of Medical and Surgical Sciences, University of Bologna, Bologna, Italy
, Valente S.
Surgical Pathology Unit, Department of Hematology, Oncology and Clinical Pathology, University of Bologna, Bologna, Italy
, Cavallini C.
Stem Wave Institute for Tissue Healing (SWITH), Gruppo Villa Maria (GVM) Care & Research - Ettore Sansavini Health Science Foundation, Lugo (Ravenna), Italy
, Tassinari R.
Stem Wave Institute for Tissue Healing (SWITH), Gruppo Villa Maria (GVM) Care & Research - Ettore Sansavini Health Science Foundation, Lugo (Ravenna), Italy
, Canaider S.
Stem Wave Institute for Tissue Healing (SWITH), Stem Wave Institute for Tissue Healing (SWITH), Lugo (Ravenna), Italy
, Pasquinelli G.
Surgical Pathology Unit, Department of Hematology, Oncology and Clinical Pathology, University of Bologna, Bologna, Italy
, Tremolada C.
Istituto Image, Milano, Italy
, Ventura C.
Stem Wave Institute for Tissue Healing (SWITH), Gruppo Villa Maria (GVM) Care & Research - Ettore Sansavini Health Science Foundation, Lugo (Ravenna), Italy
carlo.ventura@unibo.it

CellR4 2014; 2 (5): e1226

Human Stem Cell Exposure to Developmental Stage Zebrafish Extracts: a Novel Strategy for Tuning Stemness and Senescence Patterning

Canaider S.
Department of Experimental, Diagnostic and Specialty Medicine (DIMES), Unit of Histology, Embryology and Applied Biology, University of Bologna, Bologna, Italy
, Maioli M.
Department of Biomedical Sciences, University of Sassari, Sassari, Italy
, Facchin F.
Department of Experimental, Diagnostic and Specialty Medicine (DIMES), Unit of Histology, Embryology and Applied Biology, University of Bologna, Bologna, Italy
, Bianconi E.
Department of Experimental, Diagnostic and Specialty Medicine (DIMES), Unit of Histology, Embryology and Applied Biology, University of Bologna, Bologna, Italy
, Santaniello S.
Department of Biomedical Sciences, University of Sassari, Sassari, Italy
, Pigliaru G.
Department of Biomedical Sciences, University of Sassari, Sassari, Italy
, Ljungberg L.
Division of Clinical Medicine, Department of Health and Medicine, Örebro University, Örebro, Sweden
, Burigana F.
AMeC (Associazione Medicina e Complessità), Trieste, Italy
, Bianchi F.
Stem Wave Institute for Tissue Healing (SWITH), Gruppo Villa Maria (GVM) Care & Research, Ettore Sansavini Health Science Foundation, Lugo (Ravenna), Italy
, Olivi E.
Stem Wave Institute for Tissue Healing (SWITH), Gruppo Villa Maria (GVM) Care & Research, Ettore Sansavini Health Science Foundation, Lugo (Ravenna), Italy
, Tremolada C.
Istituto Image, DRI Federation, Milano, Italy
, Biava P. M.
Scientific Institute of Research and Care Multimedica, Sesto San Giovanni (Milano), Italy
biava@tiscali.it
, Ventura C.
Stem Wave Institute for Tissue Healing (SWITH), Gruppo Villa Maria (GVM) Care & Research, Ettore Sansavini Health Science Foundation, Bologna, Italy
carlo.ventura@unibo.it

CellR4 2014; 2 (5): e1215

Isolation and Characterization of Swine MIAMI Cells: A Valuable Animal Model for Adult Stem Cell Therapy

D’Ippolito G.
Geriatric Research, Education, and Clinical Center, and Research Service, Bruce W. Carter Department of Veterans Affairs Medical Center, Miami, FL, USA
dippolito@miami.edu
, Gomez L. A.
South Florida VA Foundation for Research and Education, Inc., Miami, FL, USA
, Curtis K. M.
Geriatric Research, Education, and Clinical Center, and Research Service, Bruce W. Carter Department of Veterans Affairs Medical Center, Miami, FL, USA
, Delcroix G. J.-R.
Geriatric Research, Education, and Clinical Center, and Research Service, Bruce W. Carter Department of Veterans Affairs Medical Center, Miami, FL, USA
, Hare J. M.
Interdisciplinary Stem Cell Institute, University of Miami Miller School of Medicine, Miami, FL, USA
, Hatzistergos K. E.
Interdisciplinary Stem Cell Institute, University of Miami Miller School of Medicine, Miami, FL, USA
, Oskouei B. N.
Interdisciplinary Stem Cell Institute, University of Miami Miller School of Medicine, Miami, FL, USA
, Howard G. A.
Geriatric Research, Education, and Clinical Center, and Research Service, Bruce W. Carter Department of Veterans Affairs Medical Center, Miami, FL, USA
, Reiner T.
Geriatric Research, Education, and Clinical Center, and Research Service, Bruce W. Carter Department of Veterans Affairs Medical Center, Miami, FL, USA
, Schiller P. C.
Geriatric Research, Education, and Clinical Center, and Research Service, Bruce W. Carter Department of Veterans Affairs Medical Center, Miami, FL, USA

CellR4 2014; 2 (4): e1109

Impact of Immunosuppressive Drugs on Rat Beta Cell Proliferation

Lavallard V.
Cell Isolation and Transplantation Center, Department of Surgery, Geneva University Hospitals and University of Geneva, Geneva, Switzerland
, Berney T.
Cell Isolation and Transplantation Center, Department of Surgery, Geneva University Hospitals and University of Geneva, Geneva, Switzerland
, Morel P.
Cell Isolation and Transplantation Center, Department of Surgery, Geneva University Hospitals and University of Geneva, Geneva, Switzerland
, Rouget C.
Cell Isolation and Transplantation Center, Department of Surgery, Geneva University Hospitals and University of Geneva, Geneva, Switzerland
, Bosco D.
Cell Isolation and Transplantation Center, Department of Surgery, Geneva University Hospitals and University of Geneva, Geneva, Switzerland
, Parnaud G.
Cell Isolation and Transplantation Center, Department of Surgery, Geneva University Hospitals and University of Geneva, Geneva, Switzerland
geraldine.parnaud@.unige.ch

CellR4 2014; 2 (3): e963

Magnetic Resonance Imaging of Stem Cell Transplantation in Injured Mouse Spinal Cord

Ottobrini L.
Department of Medical-Surgical Pathophysiology and Transplant, and Center of Molecular and Cellular Imaging – IMAGO, University of Milan, Milan, Italy
, Carelli S.
Department of Health Sciences, University of Milan, Milan, Italy
, Diceglie C.
Department of Medical-Surgical Pathophysiology and Transplant, and Center of Molecular and Cellular Imaging – IMAGO, University of Milan, Milan, Italy
, Lui R.
Department of Medical-Surgical Pathophysiology and Transplant, University of Milan, Milan, Italy
, Merli D.
Department of Health Sciences, University of Milan, Milan, Italy
, Giallongo T.
Department of Health Sciences, University of Milan, Milan, Italy
, Degrassi A.
Pharmacology Department, BU Oncology, Nerviano Medical Sciences, Nerviano (MI), Italy
, Russo M.
Pharmacology Department, BU Oncology, Nerviano Medical Sciences, Nerviano (MI), Italy
, Marfia G.
Department of Health Sciences, University of Milan, Milan, Italy
, Gianelli U.
Department of Medical-Surgical Pathophysiology and Transplant, University of Milan, Milan, Italy
, Bosari S.
Department of Medical-Surgical Pathophysiology and Transplant, and Center of Molecular and Cellular Imaging – IMAGO, University of Milan, Milan, Italy
, Clerici M.
Department of Medical-Surgical Pathophysiology and Transplant, and Center of Molecular and Cellular Imaging – IMAGO, University of Milan, Segrate, Milan, Italy
, Di Giulio A. M.
Center of Molecular and Cellular Imaging – IMAGO and Department of Health Sciences, University of Milan, Milan, Italy
, Lucignani G.
Center of Molecular and Cellular Imaging – IMAGO and Department of Health Sciences, University of Milan, Milan, Italy
giovanni.lucignani@unimi.it
, Gorio A.
Center of Molecular and Cellular Imaging – IMAGO and Department of Health Sciences, University of Milan, Milan, Italy
alfredo.gorio@unimi.it

CellR4 2014; 2 (2): e845

The Cardiac Regenerative Potential of Myoblasts Remains Limited Despite Improving their Survival Via Antioxidant Treatment

Beckman S. A.
Departments of Pathology, and Stem Cell Research Center, University of Pittsburgh, Pittsburgh, PA, USA
, Sekiya N.
Departments of Orthopaedic Surgery, Surgery, and Stem Cell Research Center, University of Pittsburgh, Pittsburgh, PA, USA
, Chen W. C. W.
Departments of Orthopaedic Surgery, BioEngineering, and Stem Cell Research Center, University of Pittsburgh, Pittsburgh, PA, USA
, Mlakar L.
Stem Cell Research Center, University of Pittsburgh, Pittsburgh, PA, USA
, Tobita K.
Departments of Developmental Biology, University of Pittsburgh, Pittsburgh, PA, USA
, Huard J.
Departments of Orthopaedic Surgery, Pathology, BioEngineering, and Stem Cell Research Center, University of Pittsburgh, Pittsburgh, PA, USA
jhuard@pitt.edu

CellR4 2014; 2 (1): e809

Skin Derived Stem Cells Scaffold Regenerate Axons of Injured Dorsal Root

Colleoni F.
Stem Cell Laboratory, Department of Pathophysiology and Transplantation, Università degli Studi di Milano, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Centro Dino Ferrari, Milan, Italy
, Pluderi M.
Neurosurgery Unit, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Università degli Studi di Milano, Milan, Italy
, Belicchi M.
Stem Cell Laboratory, Department of Pathophysiology and Transplantation, Università degli Studi di Milano, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Centro Dino Ferrari, Milan, Italy
, Razini P.
Stem Cell Laboratory, Department of Pathophysiology and Transplantation, Università degli Studi di Milano, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Centro Dino Ferrari, Milan, Italy
, Bresolin N.
Neurology Unit, Department of Pathophysiology and Transplantation, Università degli Studi di Milano, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Centro Dino Ferrari, Milan, Italy
, Spagnoli D.
Neurosurgery Unit, Ospedale Moriggia Pelascini, Gravedona, Italy
, Raneri F.
Neurosurgery Unit, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, University of Milan, Mila,, Italy
, Rampini P.
Neurosurgery Unit, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, University of Milan, Milan, Italy
, Gatti S.
Center for Surgical Research, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Milan, Italy
, Vergari M.
Neurophysiopathology Unit, Fondazione IRCCS Cà Granda Ospedale Maggiore Policlinico, Milan, Italy
, Grimoldi N.
Neurosurgery Unit, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Milan, Italy
nadia.grimoldi@unimi.it
, Torrente Y.
Stem Cell Laboratory, Department of Pathophysiology and Transplantation, University of Milan, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Centro Dino Ferrari, Milan, Italy
yvan.torrente@unimi.it

CellR4 2014; 2 (1): e791

Adipose-Derived Stem Cells: an Innovative Therapeutic Approach in Systemic Sclerosis and Parry-Romberg Syndrome

Vescarelli E.
Department of Experimental Medicine, Sapienza University of Rome, Rome, Italy
enrica.vescarelli@libero.it
, D’Amici S.
Department of Experimental Medicine, Sapienza University of Rome, Rome, Italy
, Onesti M. G.
Department of Plastic Reconstructive and Aesthetic Surgery, Sapienza University of Rome, Rome, Italy
, Nodale C.
Department of Experimental Medicine, Sapienza University of Rome, Rome, Italy
, Ceccarelli S.
Department of Experimental Medicine, Sapienza University of Rome, Rome, Italy
, Scuderi N.
Department of Plastic Reconstructive and Aesthetic Surgery, Sapienza University of Rome, Rome, Italy
, Angeloni A.
Department of Molecular Medicine, Sapienza University of Rome, Rome, Italy
, Marchese C.
Department of Experimental Medicine, Sapienza University of Rome, Rome, Italy

CellR4 2013; 1 (3): e528

Pretransplant Infusion of Donor Stem Cells Open Gateway to Tolerance through Induction of Regulatory T Cells and Activation of Other Allosuppressive Immune Mechanisms – Single Centre Experience in Living Donor Renal Transplantation

Trivedi H. L.
Department of Nephrology and Transplantation Medicine, G.R. Doshi and K.M. Mehta Institute of Kidney Diseases & Research Centre (IKDRC) – Dr. H.L. Trivedi Institute of Transplantation Sciences (ITS), Civil Hospital Campus, Asarwa, Ahmedabad 380016, Gujarat, India
ikdrcad1@sancharnet.in
, Vanikar A. V.
Department of Pathology, Laboratory Medicine, Transfusion Services and Immunohematology, G.R. Doshi and K.M. Mehta Institute of Kidney Diseases & Research Centre (IKDRC) – Dr. H.L. Trivedi Institute of Transplantation Sciences (ITS), Civil Hospital Campus, Asarwa, Ahmedabad 380016, Gujarat, India
, Kute V. B.
Department of Nephrology and Transplantation Medicine, G.R. Doshi and K.M. Mehta Institute of Kidney Diseases & Research Centre (IKDRC) – Dr. H.L. Trivedi Institute of Transplantation Sciences (ITS), Civil Hospital Campus, Asarwa, Ahmedabad 380016, Gujarat, India
, Patel H. V.
Department of Nephrology and Transplantation Medicine, G.R. Doshi and K.M. Mehta Institute of Kidney Diseases & Research Centre (IKDRC) – Dr. H.L. Trivedi Institute of Transplantation Sciences (ITS), Civil Hospital Campus, Asarwa, Ahmedabad 380016, Gujarat, India
, Gumber M. R.
Department of Nephrology and Transplantation Medicine, G.R. Doshi and K.M. Mehta Institute of Kidney Diseases & Research Centre (IKDRC) – Dr. H.L. Trivedi Institute of Transplantation Sciences (ITS), Civil Hospital Campus, Asarwa, Ahmedabad 380016, Gujarat, India
, Shah P. R.
Department of Nephrology and Transplantation Medicine, G.R. Doshi and K.M. Mehta Institute of Kidney Diseases & Research Centre (IKDRC) – Dr. H.L. Trivedi Institute of Transplantation Sciences (ITS), Civil Hospital Campus, Asarwa, Ahmedabad 380016, Gujarat, India
, Dave S. D.
Department of Pathology, Laboratory Medicine, Transfusion Services and Immunohematology, G.R. Doshi and K.M. Mehta Institute of Kidney Diseases & Research Centre (IKDRC) – Dr. H.L. Trivedi Institute of Transplantation Sciences (ITS), Civil Hospital Campus, Asarwa, Ahmedabad 380016, Gujarat, India

CellR4 2013; 1 (2): e382

Mesenchymal Stem Cells Promote Islet Survival In Vitro and Function In Vivo

Chen J.
Organ Transplant Institute, Fuzhou General Hospital, Xiamen University, Fuzhou, China
, Ye Y. F.
Organ Transplant Institute, Fuzhou General Hospital, Xiamen University, Fuzhou, China
, Liao L. M.
Academy of Integrative Medicine, Fujian University of Traditional Chinese Medicine, Fuzhou, China
, Cai J. Q.
Organ Transplant Institute, Fuzhou General Hospital, Xiamen University, Fuzhou, China
, Huang L. H.
Organ Transplant Institute, Fuzhou General Hospital, Xiamen University, Fuzhou, China
, Yang S. L.
Organ Transplant Institute, Fuzhou General Hospital, Xiamen University, Fuzhou, China
, Ma Y. J.
Organ Transplant Institute, Fuzhou General Hospital, Xiamen University, Fuzhou, China
, Fu Y. F.
Organ Transplant Institute, Fuzhou General Hospital, Xiamen University, Fuzhou, China
, Xu X. M.
Diabetes Research Institute, Cell Transplant Center, University of Miami, Miami, FL, USA
, Tan J. M.
Organ Transplant Institute, Fuzhou General Hospital, Xiamen University, Fuzhou, China
doctortjm@yahoo.com